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Description

Evidence for monoamine oxidase and cytochrome p450 involvement in the oxidative deamination of primaquine to carboxyprimaquine

Conceptual legacy: By linking mutagenesis, mitochondrial biology, and nutrition, Ames helped frame aging as a mechanistic, molecular process rather than an inevitable, mysterious decline

Endometriotic patients frequently show reduced Lactobacillus abundance and increased colonization by opportunistic pathogens such as Gardnerella, Prevotella, Streptococcus, and Enterococcus

Therefore, the acylcarnitines as biomarkers alone are not sufficient to predict APAP-induced hepatotoxicity, but can serve as complimentary biomarkers in combination with the current clinical markers