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GPX4 expression was associated with poor OS and DFS, especially in lung adenocarcinoma ( p = 0.008, and 0.027, respectively)

Accordingly, we found that artificial elevation of glutathione levels may induce SA accumulation in tobacco leaves, either following a single infiltration of exogenous GSH or OTC or continuous exposure to OTC ( Figure 1B , Figures S1 and S2 ) Furthermore, although GSH and OTC treatments of SA-deficient NahG tobacco did not increase free SA levels, bound SA levels were unexpectedly (1.5 to 2-fold) higher in treated NahG plants

(5) Triterpenoids: Centelloside is a triterpenoid compound isolated from gotu kola, possessing anti-inflammatory and antioxidant properties

Antibody-stained protein signal was amplified and visualized using SuperSignal West Pico PLUS chemiluminescent substrate (Thermo Fisher #34578) and imaged with a ChemiDoc MP Imaging system (Bio-Rad)