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A study found that by examining the postmortem brain tissue of suicidal patients with depression, the astrocyte-specific methylation map in the genome showed that glutamate receptor ionotropic kainate 2 and brain-rich guanosine kinase-related protein, which are associated with depressive psychopathology, were less methylated 134

Additionally, TRP channels are also expressed in microglia, contributing to their sensory and regulatory capacities

, Gaur J., Sharma R., and Haldiya K

(ii) Amino acid composition and size : these two factors should be considered when selecting a fusion partner because target proteins may require larger or smaller tags depending on their application