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In AD, the brain shows hallmark features of amyloid beta (A) plaque accumulation and neurofibrillary tangles formed by hyperphosphorylated tau protein [2], although prior to diagnosis, a series of neuropathological changes and cognitive decline occur [3]

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5) soaked with VEGF (100 ng/embryo), either alone or in combination with other compounds, were applied topically onto the CAM