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Description

Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress

J Biol Chem 293:1387413888

For example, stimulation of a macrophage with cytokines such as IFNs or TNF has profound effects on the stoichiometry of NF-B pathway components and PRRs (80), which will affect their relative availability to the signaling cascade