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Ten days oral treatment of CIA mice with the zonulin antagonist larazotide shortly before the onset of arthritis prevented the observed increase in intestinal barrier permeability for FITC-Dextran (FD4) and attenuated arthritis symptoms (Fig
Recent evidence suggests that PEGylation is generally employed to increase molecular weight and protect the payloads and/or drug nanoparticles from proteolytic degradation (Harris and Chess, 2003), thereby expanding their applicability in Alzheimer's and enabling specific designs that (i) prolong circulation timeas PEG chain can mitigate a rapid uptake by the RES (Kong et al., 2020), (ii) play a role in physical stabilityby reducing particle agglomeration and/or protein corona effect (Guerrini et al., 2018) or providing a steric stability with targeted A aggregates (Singh et al., 2022), (iii) improve BBB penetration (Kochman et al., 2026), and (v) enable controlled drug release and improved pharmacokinetics (Turjeman et al., 2015)
Patients with documented cobalamin anaphylaxis history, uncontrolled hypertension, or recent acute myocardial infarction should not receive the injection without specialist review
