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PloS One 7 (5), e37470

Under hypoxic conditions, the flux from glucose to acetyl-CoA is reduced, and saturated fatty acids are regulated by SCD1, reducing the conversion to monounsaturated fatty acids [93]

We demonstrated that Chac2-mediated GSH metabolic remodeling constitutes the core metabolic basis for the pro-inflammatory functions of N1-polarized neutrophils