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9,10 NTCP (sodium-dependent transporter) and OATP1B1/1B3 (sodium-independent transporter) are located on the sinusoidal membrane of hepatocytes and are responsible for the uptake of bile salts from portal blood into the hepatocyte

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Further emphasizing their role as signaling molecules, ROS and particularly H 2 O 2 , are also major regulators of gene expression, as evidenced by extensive genome expression reprogramming under conditions promoting H 2 O 2 accumulation (Queval et al., 2007

This protective role helps maintain cellular integrity and reduces the risk of chronic diseases associated with oxidative damage