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PMID: 39489114 J Chromatogr B Analyt Technol Biomed Life Sci Simultaneous determination of 11 oral targeted antineoplastic drugs and 2 active metabolites by LC-MS/MS in human plasma and its application to therapeutic drug monitoring in cancer patients

However, recent studies have indicated that pericytes may be lost prior to a detectable increased inflammation in the retina itself (15, 16)

In turn, several Nrf2 target genes ( Txnrd1, Srxn1, Gclm, Cul3 ) were downregulated in the N1IC AC-like model

The strategy includes 2 processes: (i) transporter-mediated permeation of a drug itself, or in form of a prodrug or nanocarrier through the BBB and in some cases the cellular barrier of brain parenchyma