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Under basal conditions, Nrf2 remains sequestered in the cytoplasm by Keap1 (186, 187)

Visual inspection cannot rule out aggregates, impurities, contamination, or chemical degradation

In hepatitis C (investigated in the HALT-C trial), the IHHA was measured on the Quantitative liver-spleen scan (QLSS) as PHM (perfused hepatic mass) and out-performed any combination of histology and routine LFT in correlation with clinical outcomes over 8 years ( Hep, 55;1019-1029, 2012 .) Early studies showed that patients with CLD have the IHHA regardless of cause and correlates with the functional hepatic mass (Am J Gastro, 92:2054-2058, 1997)

Results Mtb infection alters CBS levels in macrophages Infection of RAW 264.7 macrophages with Mtb H37Rv resulted in a 34-fold increase in the level of CBS (Fig