Key Points Alcoholic liver disease (ALD) is characterized by a complex spectrum of histological lesions, ranging from steatosis to cirrhosis Alcoholic hepatitis is a specific entity, which is associated with a fast progression to cirrhosis and with liver failure and a poor outcome in its most severe form ALD is characterized by oxidative stress, disturbance of hepatocyte metabolism, liver inflammation, modifications in the regeneration process and translocation of bacterial products from the gut microbiota into the portal blood stream Because animal models do not reproduce the complete spectrum of alcohol-induced hepatic lesions, translational research based on human samples is crucial to identify new treatment options The best-documented treatment for severe alcoholic hepatitis is corticosteroids, but this treatment is not ideal and 40% of patients still die after a short period of time The future evaluation of new strategies in severe alcoholic hepatitis should focus not only upon survival, but also on surrogate markers of outcome, with a specific plan of development Abstract Alcoholic liver disease (ALD) is a complex process that includes a wide spectrum of hepatic lesions, from steatosis to cirrhosis
Previous studies have reported positive associations between striatal DA release and cortisol levels during an IV amphetamine challenge (which was generally rewarding) [82] and during an aversive psychological stressor condition [64]
Cell-autonomous effect of selected compounds in OPC differentiation Given that NPC cultures include several neural cell types, and thus do not allow the evaluation of the direct, cell-autonomous effects of the compounds on OL differentiation/maturation, we turned to primary OPC cultures purified from neonatal (P4) mouse cortices through magnetic cell sorting (MACS)
Representative disulfide linker-based conjugates contain the cytotoxic maytansinoids conjugated to the different monoclonal antibodies
