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Description

J Clin Endocrinol Metab 86 : 58135818 Zick Y (2004) Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance

using obese murine models suggests that these models may exhibit a downregulation of -adrenergic receptors (-AR)

This has profound downstream effects, including boosting cellular metabolism, promoting fat breakdown (lipolysis), and reducing the accumulation of adipose tissue in preclinical models