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The absolute risk for these complications however is extremely uncommon, less than 1 per cent per year of use (Eckert)

Eat more sulfur-rich foods Add more broccoli, cauliflower, kale, cabbage, garlic, and onions to your meals

Predicted binding conformations suggest that the steric bulk of the O -linked cleavable moiety can be an important factor in preventing interactions with the colchicine binding site of tubulin