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NO diffuses into adjacent smooth-muscle cells, stimulates soluble guanylate cyclase, increases cyclic GMP, and lowers intracellular calcium, culminating in vasorelaxation and anti-platelet effects

Similarly, Yadav et al

These tools can integrate in silico simulations of aerosol deposition and MCC with in vivo pharmacokinetic/pharmacodynamic data to predict therapeutic outcomes and accelerate the rational design of next-generation inhalable therapies