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Similarly, supplementation of RPM (Smartamine) for Holstein multiparous cows during the transition period followed by the removal of RPM supplementation until day 72 postpartum, showed a decrease in global DNA methylation compared to cows that did not receive RPM supplementation during the entire period of evaluation ( While the maternal effects of RPM on embryonic development are well understood, the dietary paternal effects on sperm functionality and reproductive performance need further evaluation

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