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References 1.Lesho EP, Hyder A

Overall, strategies aiming to modulate the CCA TIME must shift the balance from immunosuppressive factors in favour of cytotoxic elements to enhance the antitumour response

ER stress, particularly through the PERK-eIF2-ATF4 pathway which leads to increased levels of CHOP, can contribute to ferroptosis

Training circadian clocks for cancer treatment Based on the rhythm entrainment mechanism by photic stimuli, morning bright light (MBL) exposure has been widely implemented to cure sleep problems (e.g., advanced or delayed sleep phase syndromes), neuropsychiatric diseases (e.g., autism spectrum disorder, attention deficit hyperactivity disorder, and dementia), and metabolic disorders (e.g., diabetes and obesity) in preclinical or clinical settings 52