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Woo JH, Shimoni Y, Yang WS, Subramaniam P, Iyer A, Nicoletti P, et al

Similarly, in cells expressing mouse LepR, the partial agonist variant S117A elicited approximately 60% activation of STAT3 but selectively weaker activation of both SHP2 (20%) and ERK (5%) (Supplementary Figs

Scalability of the DIA approach is demonstrated by systematically analyzing the effects of thirty kinase inhibitors in context of epidermal growth factor (EGF) signaling showing that specific protein kinases mediate EGF-dependent phospho-regulation