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A fast spliced aligner with low memory requirements

Vitamin E also prevents the metabolism of 12-LOX, a key mediator of glutamate-induced neurodegeneration, by preventing arachidonic acid from entering the catalytic site of 12-LOX and enabling vitamin E to effectively prevent neuronal degeneration (Khanna et al., 2003)

In the validation stage, an independent cohort (Cohort 2) comprising four age- and sex-matched groups (30 RBD-PD patients, 14 non-RBD-PD patients, 30 iRBD patients and 30 Ctrl subjects, all of whom underwent gold-standard video polysomnography (vPSG) assessment for the confirmation of RBD status) was included

Instead, a metal ion can act as a Lewis acid and interact with water, a Lewis base, by coordinating to a lone pair of electrons on the oxygen atom to form a hydrated metal ion (part (a) in Figure 16.12 "Effect of a Metal Ion on the Acidity of Water"), as discussed in Chapter 4 "Reactions in Aqueous Solution"