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For drug treatment, BAY-876 (MedChemExpress, HY100017

Invest 131, e140695

Many tumors operate under elevated basal reactive oxygen species (ROS) generated by oncogenic signaling, mitochondrial dysfunction, and metabolic rewiring

HAF-1 and DVE-1 were involved in the regulation of response to simulated microgravity In nematodes, some proteins, such as ATFS-1, DVE-1, UBL-5, HAF-1, CLPP-1, and LIN-65, are required for mt UPR induction by regulating the expression of mt UPR markers during the stress response 32,33,34,35