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The hypothalamic-pituitary-adrenocortical system (HPA) plays a significant role in the cause and development of depression [131]

Importantly, GPX4 was positively correlated with resistance of lung cancer cells to L-685458, lapatinib, paposilli, and topotecan, suggesting that targeting System X c /GSH/GPX4 axis could overcome drug resistance (Zhang et al., 2020