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Similarly, 10 CC were identified, where Cytoplasm (GO:0,005,737) was found with the lowest false discovery rate of 0.00051, modulating 31 targets with 12,056 background targets (CDC34, ATP5F1B, CREBBP, PPARGC1A, NTRK2, HMGCR, MAP2K1, PRKDC, IDH2, PDE2A, MAP4K4, PRKAA1, NTRK3, PTGS1, HSD11B1, ADORA1, PRKAA2, HDAC1, ALOX5, FOXO1, ESRRB, SIRT3, CDK1, RELA, EPHX2, CA1, NTRK1, HIF1A, SOD2, UBB, IGF1R) with a strength of 0.21 (Supplementary File 1)

While TZDs improve insulin sensitivity by activating PPAR and suppressing ATX, LPA signaling inhibits the expression of PPAR target genes such as adiponectin, GLUT-4, and leptin

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Alcohol-responsive hyperkinetic movement disorders-a mechanistic hypothesis