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Immunoselected STRO-3 + mesenchymal precursor cells and restoration of the extracellular matrix of degenerate intervertebral discs

Cretinism manifests in two distinct clinical phenotypes: neurological cretinism, the predominant variant, presents with intellectual disability, sensorineural deafness with mutism, strabismus, spastic diplegia, and abnormalities in posture and ambulation

Starting at 2 mg and escalating slowly is KEY, as the Phase 2 data showed a lower starting dose of 2 mg produced meaningfully fewer GI side effects than jumping in at 4 mg

The AsA-bound OsDHAR structure was refined at 1.7 resolution and contained one molecule of AsA bound to OsDHAR in the asymmetric unit (Fig