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The reduction of glutathione peroxidase 4 (GPX4), an enzyme that lowers lipid hydroperoxides and inhibits lipid peroxidation, is one important mechanism ( Neutrophils are frequently detected in a highly active state in ARDS, which exacerbates lung injury and causes the release of pro-inflammatory cytokines

10.1166/jbn.2021.3008 J

The UPR and iron starvationlike responses were independent of each other, as the latter persisted in HGT1 ire1 cells that had otherwise lost the UPR (Supplementary Figure S4C and D), but their concurrence probably caused conflicting gene regulation

All 34 patients provided a detailed medical history and underwent a physical examination