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Mechanism of Action Inhibits prostaglandin synthesis in the CNS Acts on the hypothalamus to reduce fever Minimal peripheral anti-inflammatory effect Indications (Uses) Fever (adults and children) Mild to moderate pain: Headache Toothache Muscle pain Postoperative pain Osteoarthritis Dysmenorrhea Often combined with other drugs (e.g., codeine, caffeine)

When combined with acyclovir, the Gotu Kola extract showed additive to synergistic effectshighlighting asiaticoside as a key antiviral constituent [36] In cultured monkey kidney cells, Gotu Kola extract blocked both HSV-1 and HSV-2 from multiplying in cell cultures, and this antiviral effect was even stronger when it was combined with mango (Mangifera indica L.) extract

Int J Transl Med 4(1):176196 Crews F, Nixon K, Kim D, Joseph J, Shukitt-Hale B, Qin L, Zou J (2006) BHT blocks NF-B activation and ethanol-induced brain damage

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