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GRAVES DISEASE is another autoimmune disease that affects the thyroid gland, but it causes the thyroid to become enlarged and OVERACTIVE, which results in HYPER THYROID symptoms

DHODH act as essential agents which functions within the de novo synthesis of pyrimidines in prokaryotes and eukaryotes, could reverse the increased sensitivity of SOD2 knockout cell to ferroptosis, it is also essential in cellular chromosome replication

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In the structure of LAT in complex with PLP and lysine substrate (external aldimine form), the lysine occupies a pocket created by Val63, Lys300, Ser329, and Thr330 through bidentate hydrogen bonds with Arg170, and forms a stable internal N-C covalent bond with PLP