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It's possible that lower doses of each medication might be sufficient when used together, potentially mitigating some of the side effects while maintaining efficacy

Am J Physiol 217: 710714, 1969 [DOI] [PubMed] [Google Scholar] 139.Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, Bronson RT, Fujiwara Y, Orkin SH, and Van Etten RA

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