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Collectively, those findings suggest that the interaction between NRF2 and physiological levels of ANG II in the blood play an important role in maintaining microvessel density, although the mechanisms of this interaction remain unclear

10.1016/j.freeradbiomed.2013.08.139 Free Radical Biol Med

87 Aspartate in cancer TP53 is a gene with the highest mutation frequency in human cancer

However, several drugs, including teprotumumab and BIIB-022, which target IGF-1R, have not shown good therapeutic effects in clinical trials, possibly due to the lack of reliable IGF-1R inhibition biomarkers