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Vitamin B12 deficiency is a common condition we diagnose and manage in patients of all ages, and it can present with a range of symptoms that often develop gradually and may be mistaken for other illnesses

[44] Following Zn 2+ binding, Cu + is inserted into the active site of the SOD1 monomer, primarily through a highly specific and complex interaction with CCS protein (Figure 3), which is closely tied to the formation of the stabilising intramolecular disulfide bond in SOD1 protein

This characteristic emphasizes its potent antioxidant action and supports a multifaceted thiol exchange system, which regulates cell activity

10.1002/14651858.CD000547.pub2 74 LiS.ChiangT