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By slowing this production, the body can more effectively clear low-density lipoprotein (LDL), often called "bad" cholesterol, from the blood

In the case of iron overload, the loss of SLC7A11 contributes to ferroptosis-related liver injury (Wang et al., 2017)

In addition, deletion of the GSH1 geneencoding glutamylcysteine synthetase (GCS), the enzyme catalysing the first step in glutathione synthesiswas shown to suppress an Ero1 conditional mutant, again indicating that GSH provides an additional load on Ero1 activity (Frand & Kaiser, 1998)

Structurally, the synthetic fragment retains the active signaling properties of the parent molecule