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doi: 10.1371/journal.pone.0134927

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On the other hand, when housed at the thermoneutral temperature, their body temperature remained normal, and their sleep duration, sleep patterns, and time spent in each sleep stage were similar to the control mice

Mechanisms of Protection: Upregulation of superoxide dismutase (SOD) and catalase key antioxidant enzymes Suppression of pro-inflammatory cytokine production (IL-6, TNF-) Activation of cellular repair pathways (autophagy, protein synthesis) Restoration of wound-healing fibroblast function Clinical Evidence & Research Applications Skin Regeneration & Photoaging Topical GHK-Cu has been investigated in multiple clinical trials examining its effects on sun-damaged skin (photoaging), wrinkles, skin thickness, and elasticity