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As PIMD often results in a substantial worsening of the quality of life, it is crucial to revisit this topic in order to obtain better insights into its phenomenology, pathogenesis, and management

This triple mechanism distinguishes it from dual-agonist peptides like tirzepatide (GLP-1/GIP) and single-agonist compounds like semaglutide (GLP-1 only), making it the most broadly acting incretin-class compound currently under clinical investigation