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A double-blind, placebo-controlled trial in adults with trichotillomania showed a significant 56% reduction in hair pulling with NAC, 1200 mg per day for 6 weeks followed by 2400 mg per day for another 6 weeks, compared with a 16% reduction in the placebo group, with improvements noticeable from 9 weeks

Post hoc tests revealed that there was a statistically significant reduction of -28% in GSH levels from the baseline pre-treatment time point to T1 (0.6 0.061 vs 0.43 0.039, p=0.014)

of the inciting cause)

finally, it activates fibroblast migration and upregulates collagen deposition by 320%, concurrently enhancing extracellular matrix reorganization