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Dysregulation or inappropriate activation of these signaling pathways can occur due to genetic mutations, infections, or other triggers, leading to an uncontrolled and amplified cytokine response

While caspases-4, -5 and murine caspase-11 are all capable of directly binding to LPS, differences in their binding capabilities to alternative LPS forms exist and the route of LPS internalisation may also influence their activation, as demonstrated by the selective activation of caspase-5 by OMVs from P

This accumulation causes oxidative stress-induced bacterial damage and inhibits bacterial adhesion to RAW264.7 cells

In conclusion, EMS primarily reduces oocyte quality by causing GCs apoptosis, inflammation, oxidative stress, steroidogenesis disorders, and abnormal mitochondrial energy metabolism, which also provides a therapeutic direction for improving assisted reproductive technology success rates in EMS patients