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Similarly, a single intracerebral injection of CRISPR-LNPs targeting PLK1 (sgPLK1-cLNP) enabled in vivo editing of 70% of genes in aggressive orthotopic glioblastoma cells, induced tumor cell apoptosis, inhibited tumor growth by 50%, and increased survival by 30% [293]

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The penile plaque, located at the proximal third of the penis, had an iso-hypoechoic appearance, and its dimensions were 10.1 7.65 3.02 mm, with a volume of 122 mm 3 (Fig