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In spite of the fact that animal model results are reliable, there is no extensive clinical evidence available

Accelerated wound healing through enhanced re-epithelialization has been demonstrated

The authors reported improved Morris water maze performance (reduced escape latency over the training days), increased synaptophysin (a synaptic-density marker), and lower IL-1 and TNF-, with effects attributed to PI3K/AKT signaling

The maximum mechanical stress in brain injuries is experienced far away from the surface of the brain, and at the depth of the sulci, which is also concordant with the neuropathological description of chronic traumatic encephalopathy (CTE), defined by tau phosphorylation deposits in the peri-vascular and sulci regions (McKee et al., 2015)