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a low level of oxidants, as well as the chemicals (diethyl maleate and acetaminophen) that specifically react with and deplete cellular GSH, extend the lifespan 8,26,27

In addition, DNL was independently associated with intrahepatic triglyceride levels [39], and inadequate suppression of DNL during fasting could be a key feature in NAFLD patients [38, 39]

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The activation of microglia is regulated by pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs), which can recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) (Li and Wu, 2021)