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Polymorphisms in genes encoding drug-metabolizing enzymes, such as CYP450, can alter the way drugs are processed in the liver, making genetic screening a potential tool for identifying individuals at higher risk for DILI [92]

Supporting Detoxification and Immunity GSH aids detoxification by binding to toxins in the liver for elimination and supports immunity by promoting healthy immune cell function

Chronic increases in ROS, pro-inflammatory cytokines and other damaging compounds released from immune cells and astrocytes have the ability to damage mature oligodendrocytes and OPCs, resulting in myelination impairments (Pang et al., 2003

Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy