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doi: 10.3389/fnsys.2014.00038 Received 24 November 2013 Accepted 03 March 2014 Published 13 May 2014 Volume 8 - 2014 Edited by Mikhail Lebedev, Duke University, USA Reviewed by Kimberly Simpson, University of Mississippi Medical Center, USA

The Most Studied Pathways, being the most extensively researched and containing a larger number of identified pathway genes, along with Gene-Associated Pathways, which are closely related to AD pathology-associated genes and often focused on drug development, are both more likely to yield natural products with multiple gene targets