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Indeed, in one study with daily oral administration of equal-lower doses (5 g/day) of l-ARG for a shorter period (6 weeks) compared to the current study, l-ARG supplementation was found to significantly increase both plasma and urinary NO levels in patients with organic ED of mixed etiology and unknown severity [28], therefore potentially providing additional intracavernous NO supply

Patients entering the randomized phase were then brought to their assigned target dose, gradually tapered off their concomitant AED and followed for an interval as long as 22 weeks

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Cholelithiasis was not reported in placebo-treated patients