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4.1 GSH/GSSG Regulation in Cancer, Treatment Resistance, and Ferroptosis Some cancer cells increase SLC7A11-dependent cystine uptake, GSH synthesis, NADPH production, or glutathione peroxidase activity under oxidative pressure

StatPearls Publishing, Treasure Island Bajor M, Zych AO, Graczyk-Jarzynka A, Muchowicz A, Firczuk M, Trzeciak L, Gaj P, Domagala A, Siernicka M, Zagozdzon A, Siedlecki P, Kniotek M, OLeary PC, Golab J, Zagozdzon R (2018) Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents

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The majority of iron is recycled from phagocytosis of senescent red blood cells, primarily by macrophages in the spleen, bone marrow, and liver [23]