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B12 injections may be a good option if you are feeling unusually fatigued, following a restricted diet, taking medications that can reduce B12 absorption, or looking for added wellness support as part of a broader health and aesthetic plan

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the injections are administered directly into a muscle, either in the upper arm or the hip)

Only 84 different mutations have been described in the literature that cause severe MTHFR deficiency, including 52 missense mutations, 12 splice acceptor/donor site, 8 non-sense mutations, 7 small deletions, 2 small indels, 2 start loss, and 1 gross insertion (Table 1)