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doi: 10.3389/fnut.2026.1778473 Received 31 December 2025 Revised 09 March 2026 Accepted 26 March 2026 Published 28 April 2026 Volume 13 - 2026 Edited by Huanling Lai, Guangzhou National Laboratory, China Reviewed by Jiayi Zhou, University of North Carolina at Chapel Hill, United States Mairepaiti Halimulati, The University of Texas at Austin, United States Updates Copyright 2026 Sun, Sun, Nan, Wang, Sun, Shi, Yang and Wang

The research was funded in part by the Hale Family Center for Pancreatic Cancer Research, the Lustgarten Foundation, Stand Up To Cancer, the Pancreatic Cancer Action Network, the Burroughs Wellcome Fund, a Conquer Cancer Young Investigator Award, the National Institutes of Health, and the National Cancer Institute.

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These drugs might only be effective for specific subtypes of OA, such as inflammatory OA with evident synovitis or elevated systemic inflammatory markers