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A 2021 Nature Aging study by Lee and colleagues examined MOTS-c in the context of aging directly

The chart above shows this accumulation pattern, with the sawtooth pattern representing the rise after each dose and decay between doses

Mixing different peptides together can cause degradation and loss of activity

Reactive strength (measured by means of CMJ height) displayed a tendency to reach significant effects at 24 h (depending on the correlation coefficient used to calculate SD) and eventually did at 48 h (ES 0.43, p = 0.045), which underlines a certain correlation between these two types (maximal and reactive) of muscle strength [79]