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Indeed, these time dependent HDT approaches are limited as they do not allow flexibility to manage disease through the course of an infection

Nishida Y, Ayoub E, Scruggs D, Khazaei S, Munir F, Ostermann LB, Mak PY, Baozhen K, Carter BZ, Baran N, Maiti A, Mohanty V, Chen K, Navin N, Haferlach T, Ren Z, Tong Y, Chen D, Issa GC, M Andreeff M

Bibcode:2010PNAS..107.9029K

Emphasis has been drawn to studies which recruited larger sample sizes and have reported diagnostic biomarker sensitivities and specificities (whereas many studies have not investigated diagnostic sensitivity or specificity)