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The anti-angiogenic drugs were expected to decrease or even block the oxygen and nutritional supply of tumor and then to arrest tumor growth, and displayed minimal toxic side effects to healthy tissues at the same time

Radiation-induced DNA damage is sensed by the kinases ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related protein (ATR), which activate downstream proteins to initiate the DNA damage response (reviewed in Maier et al., 2016)