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In summary, our data indicate that the cytosolic and the IMS glutathione pools are physically connected, and that cytosolic redox systems and not IMSlocalized pathways constitute the major determinants of the glutathione pool in the IMS

This regulatory plasticity drives context-dependent metabolic reprogramming in tumor cells, enabling them to adapt to fluctuating physiological demands or pathological stressors while establishing tumor-specific metabolic signatures critical for survival and progression

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Thus, even if there is no demand for NADPH (i.e, .NADP+ is low) and the oxidative phase of the pathway is not active, ribose phosphate can still be generated fromglucose-6-phosphate