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However, the controlled experiment on disc explants, although limited in scope, showed that unconstrained disc swelling can disturb integrin binding and lead to increased expression of matrix-degrading enzymes, providing support for two key steps in our hypothesis

About 70-80% of patients experience significant pain reduction after a series of 4-6 treatments over 4-6 weeks

The high sensitivity but lower specificity of the HepG2 cell model with hamster S9-mix therefore makes the model useful when a conservative approach to avoid false-negative results is the goal of the test strategy