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Interestingly, melatonin users also had a slower decline in the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) (t = 2.71, P = 0.0069), which assesses patients physical functions and daily activity [262]

40 Certain medications, such as statins, antidepressants, and antiepileptic drugs, may also induce or inhibit these enzymes, leading to significant drug interactions or unanticipated adverse reactions to caffeine