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It has been proposed that epithelial and mesenchymal cells survival relies on the signaling provided by integrins attached to a rigid surface and that culturing them in 3D gels leads to cell death by preventing attachment to a rigid surface [26]

These reactions typically include redness, swelling, and mild pain at the injection site

Cell 102 WakabayashiN.ItohK.WakabayashiJ.MotohashiH.NodaS.TakahashiS.et al (2003)