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When using a high-gauge needle like a 30G or 31G, most people report feeling very little, often just a tiny pinch or nothing at all

Proc Natl Acad Sci USA 109 , 1740617411, doi:10.1073/pnas.1207028109 (2012)

The researchers commented that the downstream execution phase of programmed cell death may also be affected by AHK-Cu

In the future, it is anticipated that the choice of appropriate quality control measures together with standard protocols for production and characterization will be taken into consideration to generate reproducible and clinically functional exosomes [117]